Paget's disease is a chronic condition of bone characterized by disorder of the normal bone remodelling process. Normal bone has a balance of forces that act to lay down new bone and take up old bone. This relationship (referred to as "bone remodelling") is essential for maintaining the normal calcium levels in our blood. In bone affected by Paget's disease, one or more localized areas of bone are affected by abnormal bone remodelling, which is disturbed and not synchronized. As a result, the bone that is formed is abnormal, enlarged, not as dense, brittle, and prone to breakage (fracture).
Paget's disease affects older skeletal bone of adults. It's estimated that 1% of adults in the U.S. have Paget's disease. There is also an extremely rare form of Paget's disease in children, referred to as juvenile Paget's disease. Paget's disease is also known as osteitis deformans and Paget disease.Get a free Quote